• Xin Tong, Dongmei An, Lili Lan, Xiaobo Zhou, Qin Zhang, Fenglai Xiao, Sung-Pa Park, Kousuke Kanemoto, Andres M Kanner, and Dong Zhou.
• Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address: saratx@163.com.
• Epilepsy Behav. 2015 Jun 1; 47: 6-10.

ObjectiveWe aimed to validate the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) for Chinese people with epilepsy (PWE).MethodsThe NDDI-E was translated into a Chinese version. A consecutive cohort of PWE from West China Hospital was recruited to test the reliability and validity of the Chinese version of the NDDI-E (C-NDDI-E). Each patient underwent the Mini International Neuropsychiatric Interview (MINI) and C-NDDI-E.ResultsA total of 202 PWE completed the psychiatric evaluation. The C-NDDI-E was easily comprehended and quickly completed by all participants. Fifty-four patients (26.7%) had current major depressive disorder (MDD) according to the MINI criteria. The Cronbach's α coefficient for the C-NDDI-E was 0.825. Receiver operating characteristic analyses showed an area under the curve of 0.936 (95% CI=0.904-0.968). At a cutoff score of >12, the C-NDDI-E had a sensitivity of 0.926, a specificity of 0.804, a positive predictive value of 0.633, and a negative predictive value of 0.967.ConclusionThe C-NDDI-E is a valuable instrument for screening MDD in Chinese PWE.Copyright © 2015 Elsevier Inc. All rights reserved.

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