• J Clin Anesth · Jul 1991

    High-dose fentanyl reduces intraoperative ventricular fibrillation in neonates with hypoplastic left heart syndrome.

    • P R Hickey and D D Hansen.
    • Department of Anesthesia, Children's Hospital, Boston, MA 02115.
    • J Clin Anesth. 1991 Jul 1; 3 (4): 295-300.

    Study ObjectiveTo determine retrospectively the effect of high-dose opiate-oxygen (O2) anesthetic technique on intraoperative ventricular fibrillation in high-risk neonates.DesignRetrospective chart review of different anesthetic techniques in a partially contemporaneous patient group (1981 to 1983).SettingCardiac anesthesia service at a university pediatric hospital.PatientsForty neonates undergoing Norwood Stage I repair of hypoplastic left heart syndrome.InterventionsHigh-dose fentanyl-O2 anesthesia in 30 neonates and low-dose morphine sulfate 50%-nitrous oxide (N2O) in 10 neonates.Measurements And Main ResultsClinical condition assessed by preoperative and intraoperative arterial blood gases, requirements for sodium bicarbonate (NaHCO3), need for inotropic and pressor support, and vital signs. Outcome assessments by intraoperative ventricular fibrillation (frequency before and after bypass) and hospital mortality. Clinical condition and hospital mortality were no different. The frequency of intraoperative ventricular fibrillation was significantly different: 3% with high-dose fentanyl and 50% with morphine-N2O (p less than 0.005).ConclusionsHigh-dose opiate-O2 anesthesia in these patients markedly decreased intraoperative ventricular fibrillation. Other clinical reports and recent experimental work suggest that this finding is due to high-dose opiates rather than the avoidance of N2O.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.