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Randomized Controlled Trial Clinical Trial
Alkalinization of mepivacaine does not alter onset of caudal anesthesia.
- J E Tetzlaff and L Rothstein.
- Department of General Anesthesia, Cleveland Clinic Foundation, OH 44195.
- J Clin Anesth. 1992 Jul 1; 4 (4): 301-3.
Study ObjectiveTo determine the effect of alkalinization of mepivacaine on onset of caudal anesthesia.DesignRandomized, blind study.SettingColon-Rectal Surgery Service of the Tertiary Center at Cleveland Clinic Foundation.PatientsYoung, healthy adults undergoing anal surgery.InterventionsAddition of bicarbonate (study group) or saline (control group) to mepivacaine.Measurements And Main ResultsAt the onset of sacral anesthesia, demographics were measured. A slightly faster onset was found in the study group (4.28 vs. 6.08 minutes), but this was not statistically significant.ConclusionsAlkalinization of mepivacaine does not significantly accelerate the onset of caudal anesthesia.
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