• J Clin Anesth · Sep 1992

    Review

    The rational pharmacology of digoxin.

    • P M Heerdt and M E Heerdt.
    • Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
    • J Clin Anesth. 1992 Sep 1; 4 (5): 419-35.

    AbstractAlthough digoxin remains one of the most widely prescribed drugs in the United States, potential pharmacodynamic and pharmacokinetic interactions between this compound and other drugs, diseases, and events commonly encountered in the perioperative period remain largely unappreciated. Furthermore, the therapeutic benefit of discontinuing or initiating digoxin treatment preoperatively remains unclear. We present a basic review of current knowledge regarding digoxin pharmacology and examine those concepts from the perspective of clinical anesthesiologists.

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