• Jeffrey I Traylor, Rajan Patel, Ahmed Habib, Matthew Muir, Dhiego Chaves de Almeida Bastos, Ganesh Rao, and Sujit S Prabhu.
• Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
• World Neurosurg. 2019 Dec 1; 132: e124-e132.

BackgroundPosterior fossa tumors are rare in adults and pose a challenge to treat due to the bony contour of the posterior fossa, complex anatomical structures including deep venous sinuses, and the proximity of the fourth ventricle and brain stem. We describe our experience with laser interstitial thermal therapy (LITT) for the management of brain metastases and radiation necrosis of the posterior fossa.MethodsWe retrospectively analyzed 13 patients with metastases and radiation necrosis of the posterior fossa managed with LITT.ResultsThirteen patients with histopathologically confirmed radiation necrosis (n = 5) and metastases (n = 8) of the posterior fossa underwent LITT. The median preoperative tumor was 4.66 cm3, and median postoperative ablation cavity volume was 6.29 cm3. The median volume of the ablation cavity was decreased to 2.90 cm3 at a 9-month follow-up. The median volume of peritumoral edema was 12.25 cm3, which fell to a median of 5.77 cm3 at 1-month follow-up. The median progression-free survival was 7 months (range, 3-14 months) and the mean overall survival was 40 months (range, 2-49 months) after LITT. There were no intraoperative complications. One patient experienced palsy of the seventh and eighth cranial nerves on follow-up, attributable to LITT.ConclusionsLesions of the posterior fossa are challenging to treat given their proximity to the dura and venous sinuses. Our findings demonstrate that LITT ablation may be a safe and feasible option for metastases and radiation necrosis of the posterior fossa. Larger studies are needed to confirm the efficacy of this approach.Copyright © 2019 Elsevier Inc. All rights reserved.

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