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Clinical Trial Controlled Clinical Trial
Effect of folic acid supplementation on plasma zinc concentrations of young women.
- Timothy J Green, C Murray Skeaff, Susan J Whiting, and Rosalind S Gibson.
- Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand. tim.green@stonebow.otago.ac.nz
- Nutrition. 2003 Jun 1; 19 (6): 522-3.
ObjectiveWomen of reproductive age are advised to consume supplements or fortified foods containing at least 400 microg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status.MethodsSeventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 microg/d folic acid supplement.ResultsAt 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213).ConclusionsFolic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.
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