• Ana M Feoli, Cíntia Roehrig, Liane N Rotta, Adriane H Kruger, Karine B Souza, Alexandre M Kessler, Sandro V Renz, Ana M Brusque, Diogo O Souza, and Marcos L S Perry.
• Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Porto Alegre, Rio Grande do Sul, Brazil.
• Nutrition. 2003 Sep 1; 19 (9): 789-93.

ObjectivesBecause dietary fat composition is determinant for serum cholesterol level, which is related to cardiovascular disease, we evaluated the effects of diets containing saturated (coconut oil) or polyunsaturated fatty acids (soybean oil) supplemented or not with dietary cholesterol on serum and liver lipid composition in two animal species.MethodsMale Wistar rats (21 d old) were assigned to one of seven groups and fed with commercial diet or diets containing 5% or 20% soybean oil or 20% coconut oil with or without 1% cholesterol. Chicks were assigned to one of four groups and fed with diets containing 15% soybean oil or 15% coconut oil with or without 1% cholesterol.ResultsIn rats, the accumulations of hepatic cholesterol and triacylglycerols were higher in the group fed 20% soybean oil and 1% cholesterol than in the group fed 20% coconut fat and 1% cholesterol. The highest serum levels of cholesterol and triacylglycerols were observed in the group fed coconut oil and cholesterol, compared with the group fed soybean oil and cholesterol. Triacylglycerol, high-density lipoprotein, and total cholesterol serum levels increased with diet containing coconut oil and cholesterol. In chicks, the highest hepatic cholesterol accumulation occurred in the group fed 15% coconut fat and 1% cholesterol. Total and high-density lipoprotein cholesterol levels increased with diet containing coconut oil and cholesterol, although none of these diets modified serum triacylglycerol levels.ConclusionsThe type of experimental animal model and the diet composition influence lipid metabolism.

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