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- S Wang and K M Young.
- Menzies Research Institute Tasmania, University of Tasmania, Hobart 7000, Australia.
- Neuroscience. 2014 Sep 12;276:148-60.
AbstractCNS white matter is subject to a novel form of neural plasticity which has been termed "myelin plasticity". It is well established that oligodendrocyte generation and the addition of new myelin internodes continue throughout normal adulthood. These new myelin internodes maybe required for the de novo myelination of previously unmyelinated axons, myelin sheath replacement, or even myelin remodeling. Each process could alter axonal conduction velocity, but to what end? We review the changes that occur within the white matter over the lifetime, the known regulators and mediators of white matter plasticity in the mature CNS, and the physiological role this plasticity may play in CNS function.Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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