• Clin J Pain · May 2003

    Randomized Controlled Trial Clinical Trial

    The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine.

    • Gary J McCleane.
    • Rampark Pain Centre, Lurgan, Northern Ireland, United Kingdom. gary@mccleane.freeserve.co.uk
    • Clin J Pain. 2003 May 1; 19 (3): 200-1.

    AimTo investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.MethodA double-blind, placebo-controlled crossover study of 30 adult subjects.ResultsMean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.ConclusionThe CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.

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