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- C M White, R A Gailey, G M Levin, and T Smith.
- Drug Information Center, Hartford Hospital, CT 06102, USA.
- Ann Pharmacother. 1997 Feb 1; 31 (2): 178-80.
ObjectiveTo report a case of venlafaxine overdose.Case SummaryA 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafaxine was discontinued, and no further sequelae were seen.DiscussionTo our knowledge, this is the first reported case of venlafaxine overdose that resulted in a generalized seizure. Based on nonoverdose pharmacokinetics and pharmacodynamics of venlafaxine and the potential risks of available interventions, no emergent therapy was instituted.ConclusionsThe venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae.
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