• J. Neuroimmunol. · May 2015

    Intravenous immunoglobulin may reduce relapse frequency in neuromyelitis optica.

    • Shanthi Viswanathan, Anna H Y Wong, Amy M L Quek, and Nobuhiro Yuki.
    • Department of Neurology, Kuala Lumpur Hospital, Malaysia. Electronic address: shivenda70@yahoo.com.
    • J. Neuroimmunol. 2015 May 15; 282: 92-6.

    ObjectivesTo evaluate the use of intravenous immunoglobulin (IVIG) in preventing relapses in patients with neuromyelitis optica (NMO) and its spectrum disorders (NMOSDs).MethodsSix NMO/NMOSD patients who were treated with IVIG induction dose followed by 2- to 3- monthly infusions were retrospectively identified. Annualized relapse rates (ARR) and Expanded Disability Status Scale (EDSS) pre- and post-IVIG were recorded.ResultsMedian number of relapses and median ARR significantly reduced from 8.0 to 1.0 and 0.75 to 0.15 (p<0.05) respectively. Median EDSS of 6.5 remained the same. Median duration of treatment was 4.0 years.ConclusionIVIG may be used to reduce the relapse frequency in patients with NMO/NMOSD.Copyright © 2015 Elsevier B.V. All rights reserved.

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