• J L Vincent, G Slotman, P A Van Leeuwen, M Shelly, S Nasraway, A Tenaillon, J Bander, and G Friedman.
• Department of Intensive Care, Erasme University Hospital, Brussels, Belgium.
• J Crit Care. 1999 Jun 1; 14 (2): 69-72.

PurposeThe purpose of this study was to investigate the effects of interleukin-1 receptor antagonist (IL-1ra) on myocardial function in septic patients.Materials And MethodsA subgroup of patients from a prospective, randomized, double-blind, placebo-controlled, multicenter trial was studied from 63 academic medical centers in the United States, Canada, and Europe. A subgroup of 71 patients with severe sepsis in whom vasoactive support was little altered during the study was included. The patients were randomized to receive either placebo (n = 29) or IL-1ra at a dose of 1 mg/kg/h (n = 20) or 2 mg/kg/h (n = 22).ResultsHemodynamic measurements were taken at baseline, and 1, 2, 3, 4, 8, and 12 hours after placebo or IL-1ra administration. No significant differences in hemodynamic parameters were observed between the groups or over time during the study period.ConclusionsIL-1ra administration has no effect on cardiac function in septic patients.

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