Journal of critical care
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Journal of critical care · Jun 1999
Comparative StudyInterleukin 1 receptor antagonist and E-selectin concentrations: a comparison in patients with severe acute pancreatitis and severe sepsis.
This prospective clinical study was designed to compare interleukin 1 receptor antagonist (IL-1ra) and E-selectin concentrations in patients with severe acute pancreatitis to those with severe sepsis. ⋯ This study shows that IL-1ra and E-selectin are released in acute severe pancreatitis, and the levels seem to be comparable to those in patients with severe sepsis. Concentrations of IL-1ra and E-selectin correlate to the development of multiorgan failure as indicated by high SOFA scores during the first week of disease.
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Journal of critical care · Jun 1999
Randomized Controlled Trial Multicenter Study Clinical TrialIL-1ra administration does not improve cardiac function in patients with severe sepsis.
The purpose of this study was to investigate the effects of interleukin-1 receptor antagonist (IL-1ra) on myocardial function in septic patients. ⋯ IL-1ra administration has no effect on cardiac function in septic patients.
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Journal of critical care · Jun 1999
Gut mucosal atrophy after a short enteral fasting period in critically ill patients.
The purpose of this study was to evaluate the presence of gut mucosal atrophy and changes in mucosal permeability in critically ill patients after a short fasting period. ⋯ We found that a short period of enteral fasting was associated with significant duodenal mucosal atrophy and abnormal gut permeability in critically ill patients.
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Journal of critical care · Jun 1999
Influence of epinephrine and norepinephrine on intestinal villous blood flow during endotoxemia.
The objective of this study was to determine the effects of epinephrine and norepinephrine on mucosal villous blood flow in a normotensive model of endotoxemia. ⋯ In this experimental rat model, the catecholamines epinephrine and norepinephrine in a dosage of 0.2 microg.kg(-1).min(-1) neither diminish nor improve mucosal villous blood flow during the early phase of endotoxemia.
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Journal of critical care · Jun 1999
Partial liquid ventilation influences pulmonary histopathology in an animal model of acute lung injury.
The aim of this study was to assess the effect of partial liquid ventilation (PLV) and conventional mechanical ventilation (CMV) in the pattern of distribution of lung injury in a rabbit model of acute lung injury. ⋯ PLV is associated with significant attenuation of lung injury, in comparison to CMV. This effect is predominantly due to attenuation of injury in the dependent region of the lung.