• Neuroscience · Dec 2019

    A Standardized Anxiety Quotient in Elevated Open Platform Task Quantifies Rodent Anxiogenic Tendency with Improved Reliability and Sensitivity.

    • William Z Suo, David W Peng, Prabhakar Singh, and Xue-Feng Ding.
    • Laboratory for Alzheimer's Disease & Aging Research, Veterans Affairs Medical Center, Kansas City, MO 64128, USA; Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66170, USA; Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66170, USA; University of Kansas Alzheimer's Disease Center (KU ADC), Kansas City, KS 66170, USA. Electronic address: William.suo@va.gov.
    • Neuroscience. 2019 Dec 15; 423: 12-17.

    AbstractSensitivity and reliability of animal behavioral assessment methods are critical for successful translation of in vitro findings to in vivo. Here we report a data transformation process in the elevated open platform task that generates a novel parameter, namely peak tolerance of fear (PTF) or its inversely correlated equivalent of anxiety quotient (AQ), to measure anxiogenic tendency in rodent. As compared to traditional parameters such as travel distance, time, or entries, PTF or AQ displays largely reduced data dispersion not only ingroup but also cross-study and cross-cohort, therefore representing a significant improvement of the methodology for rodent anxiety assessment.Published by Elsevier Ltd.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…