• Stefano Caproni, Elisa Bianchi, Letizia M Cupini, Ilenia Corbelli, Ettore Beghi, Paolo Calabresi, Paola Sarchielli, and SAMOHA Study Group.
• Clinica Neurologica, Azienda Ospedaliera - Università di Perugia, Perugia, Italy. stefano.caproni@gmail.com.
• Bmc Neurol. 2015 May 21; 15: 85.

BackgroundThe management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, particularly for the responder rate after a successful withdrawal treatment. The purpose of this study was to investigate the role of demographic and clinical characteristics as well as the score of Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Disability Questionnaire and Leeds Dependence Questionnaire in predicting a response after a successful withdrawal treatment in patients with MOH.MethodsThis ancillary study is part of a randomized trial that demonstrated the safety and the efficacy of a 3-month treatment with sodium valproate (VPA) (800 mg/day vs placebo) in MOH. Demographic and clinical characteristics and questionnaire results were obtained from the entire sample.ResultsA significant correlation was found only between MOH relapse and the total MSQ score, the Role Preventive sub-scale and the Emotional Function sub-scale, suggesting a poorer quality of life in non responders.ConclusionA high MSQ score could be associated with a poor short-term outcome in MOH patients after a successful treatment with detoxification followed by a new treatment.

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