• Michael T Ganter, Uwe Schneider, Michel Heinzelmann, Michael Zaugg, Eliana Lucchinetti, Andreas Zollinger, and Christoph K Hofer.
• Department of Anesthesia and Perioperative Care, University of California, San Francisco General Hospital, San Francisco, CA 94110, USA. mt.ganter@gmail.com
• J Clin Anesth. 2007 Dec 1; 19 (8): 569-75.

Study ObjectivesTo continuously measure arterial blood gases (ABGs), to calculate the percentage of anticipated changes over time, and to develop recommendations for sampling frequencies of arterial blood gases in patients undergoing thoracoscopic surgery.DesignProspective, observational clinical trial.SettingUniversity hospital.Patients43 consecutive elective patients undergoing thoracoscopic surgery with one-lung ventilation.Interventions And MeasurementsA Paratrend 7 probe for continuous arterial partial pressure of oxygen and arterial partial pressure of carbon dioxide measurement was introduced through a radial artery cannula in the awake patient before surgery. Data were collected throughout the procedure until patients left the operating room. Afterward, time courses of arterial blood gas values were transformed into frequency space by fast Fourier transform analysis, and the expected deviations in arterial blood gases were calculated over time.Main ResultsForty-three consecutive patients undergoing thoracoscopic surgery were included, and arterial blood gas values were measured during a total of 141.5 h. Critical arterial partial pressure of oxygen values ConclusionsCurrent standards to monitor arterial blood gases are not sufficient to detect and prevent hypoxemic events during thoracoscopic surgery with one-lung ventilation. Intermittent arterial blood gas analyses must be performed more frequently, up to every 10 minutes, to detect changes of 20% in arterial partial pressure of oxygen.

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