• Julie Duron, Lénaic Monconduit, and Paul Avan.
• School of Medicine, University Clermont Auvergne, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France; UMR INSERM 1107, School of Medicine, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France; Audioconsulting, Audition Conseil, 16 rue Blatin, 63000 Clermont-Ferrand, France. Electronic address: Julie.duron@etu.uca.fr.
• Neuroscience. 2020 Feb 1; 426: 129-140.

AbstractHyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system these abnormalities arise remains open, particularly when hyperacusis comes without sensorineural hearing loss. Here we used acute intraperitoneal administration of sodium salicylate (150 mg/kg) in rats, enough to produce > 10-dB decrease in acoustic startle threshold with mild hearing loss at low frequencies (<10 kHz). Anesthesia, necessary for middle-ear-reflex (MEMR) threshold measurements, abolished the olivocochlear efferent reflex but not the MEMR acting on frequencies < 10 kHz, and its mean threshold increased from 55 dB SPL in controls to 80 dB SPL in salicylate-treated animals 60-90 minutes after injection, with an about 3-dB increase in acoustic energy reaching the cochlea. The mean latencies of auditory brainstem-evoked responses (ABR) conspicuously decreased after salicylate, by 0.25 millisecond at 6 kHz at every level, a frequency-dependent effect absent above 12 kHz. A generic model of loudness based upon cross-frequency coincidence detection predicts that with such timing changes, a transient sound may seem as loud at <40 dB SPL as it does in controls at >60 dB SPL. Candidate circuits able to act at the same time on the startle reflex, the MEMR and ABRs may be serotoninergic, as salicylate is known to increase brain serotonin and 5-HT neurons participate in MEMR and ABR circuits.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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