• Nutrition · Oct 2008

    Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women.

    • Justine Beck, Luigi Ferrucci, Kai Sun, Linda P Fried, Ravi Varadhan, Jeremy Walston, Jack M Guralnik, and Richard D Semba.
    • Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
    • Nutrition. 2008 Oct 1; 24 (10): 964968964-8.

    ObjectiveThe objective of this study was to determine whether total serum carotenoids, alpha-tocopherol, selenium, and obesity were independently associated with oxidized low-density lipoproteins (ox-LDLs) in moderately to severely disabled older women living in the community.MethodsSerum ox-LDLs, carotenoids, alpha-tocopherol, and selenium were measured in a population-based sample of 543 moderately to severely disabled women > or = 65 y in the Women's Health and Aging Study I in Baltimore, Maryland.ResultsTotal serum carotenoids, smoking, overweight (body mass index 25-29.9 kg/m(2)), and obesity (body mass index > or = 30 mg/kg(2)) were significantly associated with the ox-LDL/LDL cholesterol ratio after adjusting for age, C-reactive protein, and chronic diseases. alpha-Tocopherol and selenium were not significantly associated with the ox-LDL/LDL cholesterol ratio.ConclusionOlder women who are overweight or obese or who have low total serum carotenoids are more likely to have higher lipoprotein oxidation. Weight reduction in overweight/obese women and increased intake of carotenoid-rich foods may potentially reduce lipoprotein oxidation.

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