• Neuroscience · Feb 2021

    Review

    Kainate receptors, homeostatic gatekeepers of synaptic plasticity.

    • Sergio Valbuena and Juan Lerma.
    • Instituto de Neurociencias UMH-CSIC, 03550 San Juan de Alicante, Spain. Electronic address: svalbuena@umh.es.
    • Neuroscience. 2021 Feb 21; 456: 17-26.

    AbstractExtensive research over the past decades has characterized multiple forms of synaptic plasticity, identifying them as key processes that allow the brain to operate in a dynamic manner. Within the wide variety of synaptic plasticity modulators, kainate receptors are receiving increasing attention, given their diversity of signaling mechanisms and cellular expression profile. Here, we summarize the experimental evidence about the involvement of kainate receptor signaling in the regulation of short- and long-term plasticity, from the perspective of the regulation of neurotransmitter release. In light of this evidence, we propose that kainate receptors may be considered homeostatic modulators of neurotransmitter release, able to bidirectionally regulate plasticity depending on the functional history of the synapse.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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