• Shailesh Agarwal, Kelley M Kidwell, Casey T Kraft, Jeffrey H Kozlow, Michael S Sabel, Kevin C Chung, and Adeyiza O Momoh.
• Ann Arbor, Mich. From the Section of Plastic Surgery, Department of Surgery, the Section of Surgical Oncology, Department of Surgery, University of Michigan Medical School; and the Department of Biostatistics, School of Public Health, University of Michigan.
• Plast. Reconstr. Surg. 2015 Mar 1; 135 (3): 661-70.

BackgroundRecent studies suggest that the decisions to undergo breast reconstruction and contralateral prophylactic mastectomy are closely related. In this article, the relationship between method of reconstruction and decision to undergo contralateral prophylactic mastectomy is described. Recent trends in contralateral use in the context of literature questioning its oncologic benefit are also evaluated.MethodsFemale patients with unilateral breast cancer were identified and data extracted from the Surveillance, Epidemiology, and End Results database from 2000 through 2010. Logistic regression analyses were performed to study the relationship between having contralateral prophylactic mastectomy and key demographic, oncologic, and reconstructive factors among women with unilateral breast cancer.ResultsA total of 157,042 patients with unilateral breast cancer were included. The contralateral prophylactic mastectomy rate increased from 7.7 percent to 28.3 percent during the study period, and the proportion of reconstructed patients who underwent contralateral prophylactic mastectomy increased from 19 percent to 46 percent. Reconstruction was associated with higher odds of contralateral prophylactic mastectomy (OR, 2.79; 95 percent CI, 2.70 to 2.88; p < 0.0001). Among women who had reconstruction, implant-based reconstruction was associated with significantly higher odds of contralateral prophylactic mastectomy than autologous tissue reconstruction (OR, 1.38; p < 0.0001).ConclusionsThis study confirms that reconstruction and the decision to undergo contralateral prophylactic mastectomy are closely related, with implant reconstruction dominating in these patients. Given the close relationship between reconstruction and the choice for contralateral prophylactic mastectomy, plastic surgeons should play an active role in educating patients to avoid decisions made based on inaccurate information.Clinical Question/Level Of EvidenceRisk, II.

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