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- Charles A Scanga and JoAnne L Flynn.
- Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- Cell Host Microbe. 2010 Mar 18; 7 (3): 177-9.
AbstractEicosanoids can have either proinflammatory effects or anti-inflammatory effects. Tobin and colleagues use a forward genetic screen in zebrafish to identify a key eicosanoid enzyme, leukotriene A(4) hydrolase (LTA(4)H), that controls susceptibility to mycobacterial infection. They also demonstrate that polymorphisms in LTA(4)H are associated with susceptibility to mycobacteria in humans.Copyright 2010 Elsevier Inc. All rights reserved.
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