Cell host & microbe

The most recent articles from: March 2010

  • Cell host & microbe · Mar 2010

    Mycobacterial infections and the inflammatory seesaw.

    Eicosanoids can have either proinflammatory effects or anti-inflammatory effects. Tobin and colleagues use a forward genetic screen in zebrafish to identify a key eicosanoid enzyme, leukotriene A(4) hydrolase (LTA(4)H), that controls susceptibility to mycobacterial infection. They also demonstrate that polymorphisms in LTA(4)H are associated with susceptibility to mycobacteria in humans.

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