• Biol. Pharm. Bull. · Jan 2011

    Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous immunization device.

    • Kazuhiko Matsuo, Yumiko Ishii, Ying-Shu Quan, Fumio Kamiyama, Hideo Asada, Yohei Mukai, Naoki Okada, and Shinsaku Nakagawa.
    • Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565–0871, Japan.
    • Biol. Pharm. Bull. 2011 Jan 1; 34 (12): 1835-40.

    AbstractThe development of a simple, easy-to-use, and non-invasive vaccination system is in high demand. For transcutaneous immunization (TCI), we previously developed a hydrogel patch formulation that accelerates the penetration of an antigen (Ag) through the stratum corneum (SC) and effectively elicits Ag-specific immune responses. The present studies were performed to optimize the composition and assess the safety of the patch formulation. A hydrogel patch with a water content ratio of 5% more effectively induced an immune response compared to patches with a different composition, suggesting that the moisture content of the hydrogel patch formulation has optimal ratio for SC hydration to promote Ag penetration through the SC. TCI using a hydrogel patch induced few local and systemic adverse reactions. Based on these results, we are now advancing translational research to evaluate the safety and efficacy of our novel TCI system in humans.

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