• Ka Ting Ng, Jasmine Li Ling Yap, and Pei En Kwok.
• Department of Anaesthesiology, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: katingng1@gmail.com.
• J Clin Anesth. 2020 Aug 1; 63: 109782.

BackgroundLow level of fibrinogen is a risk factor of perioperative bleeding, which is a major complication in surgical patients. However, the safety and efficacy of fibrinogen supplementation with fibrinogen concentrate to minimize postoperative bleeding remains unclear.ObjectivesThe primary aim of this review was to investigate the effect of fibrinogen concentrate in postoperative blood loss in adult surgical patients.DesignSystematic review and meta-analysis.Data SourcesDatabases of MEDLINE, EMBASE and CENTRAL were searched from their start date until July 2019.Eligibility CriteriaAll randomized clinical trials comparing intravenous fibrinogen concentrate and placebo in adult surgical patients were included, regardless of type of surgery. Observational studies, case reports, case series and non-systematic reviews were excluded.ResultsThirteen trials (n = 900) were included in this review. In comparison to placebo, fibrinogen concentrate significantly reduced the first 12-hour postoperative blood loss, with a mean difference of -134.6 ml (95% CI -181.9 to -87.4). It also significantly increased clot firmness in thromboelastometry (FIBTEM) with a mean difference of 2.5 mm (95%CI 1.1 to 3.8). No significant differences were demonstrated in the adverse events associated with fibrinogen concentrate use, namely incidence of thromboembolism, myocardial infarction and acute kidney injury.ConclusionsIn this meta-analysis of 13 randomized trials, low level of evidence and substantial heterogeneity with small sample size limit strong recommendation on the use of fibrinogen concentrate in adult surgical patients. However, its use is tolerable without any notable adverse events.Trial RegistrationCRD42019149164.Copyright © 2020 Elsevier Inc. All rights reserved.

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