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Acta Anaesthesiol Scand · Apr 1983
Effect of age on the establishment of muscle paralysis induced in anaesthetized adult subjects by ORG NC 45.
- A A d'Hollander, M Nevelsteen, L Barvais, and M Baurain.
- Acta Anaesthesiol Scand. 1983 Apr 1; 27 (2): 108-10.
AbstractThe establishment of muscle paralysis produced by a single dose of 70 micrograms . kg-1 of ORG NC 45 was studied in 30 healthy anaesthetized patients, aged 15-85 years, by recording adductor pollicis isometric mechanical activity-twitch height (TH). Significant correlations were observed between age and the latency of ORG NC 45 action, defined as the reduction of TH to 95% of its initial value (r:0.315, P less than 0.05) and between age and the onset time, defined as the time elapsing between ORG NC 45 administration and maximum TH depression observed (r:0.454, P less than 0.005). Correlation between age and maximum TH depression was not significant. These results show that if the maximum TH depression observed after a standard dose of ORG NC 45 is not altered by the age of the patient, the establishment of the paralysis is delayed by ageing.
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