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Neuroimaging Clin. N. Am. · May 2020
ReviewRole of Magnetoencephalography in the Early Stages of Alzheimer Disease.
- Fernando Maestú and Alberto Fernández.
- Department of Experimental Psychology, Complutense University of Madrid, Madrid, Spain; Centro de Tecnología Biomédica, Campus de Montegancedo de la UPM, Pozuelo de Alarcón, Madrid 28223, Spain. Electronic address: fmaestuu@ucm.es.
- Neuroimaging Clin. N. Am. 2020 May 1; 30 (2): 217-227.
AbstractAs synaptic dysfunction is an early manifestation of Alzheimer disease (AD) pathology, magnetoencephalography (MEG) is capable of detecting disruptions by assessing the synchronized oscillatory activity of thousands of neurons that rely on the integrity of neural connections. MEG findings include slowness of the oscillatory activity, accompanied by a reduction of the alpha band power, and dysfunction of the functional networks. These findings are associated with the neuropathology of the disease and cognitive impairment. These neurophysiological biomarkers predict which patients with mild cognitive impairment will develop dementia. MEG has demonstrated its utility as a noninvasive biomarker for early detection of AD.Published by Elsevier Inc.
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