• World Neurosurg · Aug 2020

    Deep brain stimulation improves motor function in rats with spinal cord injury by increasing synaptic plasticity.

    • Min Wang, Lina Jia, Xiaobo Wu, Zuoli Sun, Zheng Xu, Chao Kong, Lin Ma, Ruifeng Zhao, and Shibao Lu.
    • Department of Orthopedics, Xuanwu Hospital Capital Medical University, Beijing, China; The fourth Department of Orthopedics, Jincheng General Hospital, Jincheng, Shanxi Province, China.
    • World Neurosurg. 2020 Aug 1; 140: e294-e303.

    ObjectiveTo investigate the effect of deep brain stimulation (DBS) on rats with spinal cord injury (SCI) and its possible molecular mechanism.MethodsA rat SCI model was prepared using a modified Allen method. The animals were randomly divided into 3 groups (n = 12 per group): the sham group, the SCI group, and the SCI + DBS group. Then, DBS was applied to the rats in the SCI + DBS group for half an hour per day for 4 weeks. Basso, Beattie, and Bresnahan scores were used to assess spinal function.ResultsDBS significantly improved hindlimb motor function in SCI rats, and the protein expression levels of brain-derived neurotrophic factor, the mammalian target of rapamycin, tropomyosin-related kinase B, protein kinase B, p70 ribosomal S6 protein kinase, postsynaptic density protein 95, and synaptophysin increased correspondingly.ConclusionsDBS improves motor function in rats with SCI by increasing synaptic plasticity via tropomyosin-related kinase B-protein kinase B-mammalian target of rapamycin pathway.Copyright © 2020 Elsevier Inc. All rights reserved.

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