• Wesley M Durand, Alan H Daniels, David K Hamilton, Peter Passias, Han Jo Kim, Themistocles Protopsaltis, Virginie LaFage, Justin S Smith, Christopher Shaffrey, Munish Gupta, Eric Klineberg, Frank Schwab, Doug Burton, Shay Bess, Christopher Ames, Robert Hart, and International Spine Study Group.
• Alpert Medical School of Brown University, Providence, Rhode Island, USA.
• World Neurosurg. 2020 Sep 1; 141: e239-e253.

ObjectivePatients with ASD show complex and highly variable disease. The decision to manage patients operatively is largely subjective and varies based on surgeon training and experience. We sought to develop models capable of accurately discriminating between patients receiving operative versus nonoperative treatment based only on baseline radiographic and clinical data at enrollment.MethodsThis study was a retrospective analysis of a multicenter consecutive cohort of patients with ASD. A total of 1503 patients were included, divided in a 70:30 split for training and testing. Patients receiving operative treatment were defined as those undergoing surgery up to 1 year after their baseline visit. Potential predictors included available demographics, past medical history, patient-reported outcome measures, and premeasured radiographic parameters from anteroposterior and lateral films. In total, 321 potential predictors were included. Random forest, elastic net regression, logistic regression, and support vector machines (SVMs) with radial and linear kernels were trained.ResultsOf patients in the training and testing sets, 69.0% (n = 727) and 69.1% (n = 311), respectively, received operative management. On evaluation with the testing dataset, performance for SVM linear (area under the curve =0.910), elastic net (0.913), and SVM radial (0.914) models was excellent, and the logistic regression (0.896) and random forest (0.830) models performed very well for predicting operative management of patients with ASD. The SVM linear model showed 86% accuracy.ConclusionsThis study developed models showing excellent discrimination (area under the curve >0.9) between patients receiving operative versus nonoperative management, based solely on baseline study enrollment values. Future investigations may evaluate the implementation of such models for decision support in the clinical setting.Copyright © 2020 Elsevier Inc. All rights reserved.

17 keywords...

hide…