• Br J Anaesth · Oct 1980

    Randomized Controlled Trial Comparative Study Clinical Trial

    Effects of concentration of local anaesthetic drugs in extradural block.

    • D B Scott, J H McClure, R M Giasi, J Seo, and B G Covino.
    • Br J Anaesth. 1980 Oct 1; 52 (10): 1033-7.

    AbstractAn increase in the concentration of bupivacaine from 0.5% to 0.75% and etidocaine from 1.0% to 1.5% for extradural block resulted in a more rapid onset of sensory analgesia and motor blockade, a greater frequency of adequate analgesia,a greater depth of motor block and a longer duration of sensory analgesia and motor blockade. An increase in the concentration of prilocaine from 2% to 3% failed to reveal any significant advantage. The use of the more concentrated solutions of bupivacaine and etidocaine would appear to afford significant clinical advantages in extradural anaesthesia for surgery.

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