• Preventive medicine · Dec 1974

    Acute viral gastroenteritis.

    • A Z Kapikian.
    • Prev Med. 1974 Dec 1; 3 (4): 535542535-42.

    AbstractTwo virus-like particles have been found to be associated with acute viral gastroenteritis. One, a 270-nm parvovirus-like particle (the Norwalk agent), was visualized and recognized by immune electron microscopy in an infectious stool filtrate derived from a community outbreak of nonbacterial gastroenteritis. It appears to be one of the etiologic agents of a usually self-limited form of gastroenteritis which commonly occurs in community outbreaks. The other, a 70-nm reovirus-like particle, has been observed by electron microscopy in specimens from infants and children with severe diarrhea in many parts of the world. The reovirus-like particle may emerge as a major etiologic agent of diarrhea of infants and young children.

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