• Transl Res · Feb 2015

    Review

    Interferon regulatory factors: critical mediators of human lupus.

    • Mark A Jensen and Timothy B Niewold.
    • Division of Rheumatology, Department of Immunology, Mayo Clinic, Rochester, Minn.
    • Transl Res. 2015 Feb 1; 165 (2): 283-95.

    AbstractThe pathogenesis of systemic lupus erythematosus (SLE) is multifactorial, and the interferon regulatory factors (IRFs) play an important role. Autoantibodies formed in SLE target nuclear antigens, and immune complexes formed by these antibodies contain nucleic acid. These immune complexes can activate antiviral pattern recognition receptors (PRRs), resulting in the downstream activation of IRFs, which can induce type I interferon (IFN-I) and other inflammatory mediators. Genetic variations in IRFs have been associated with susceptibility to SLE, and current evidence supports the idea that these polymorphisms are gain of function in humans. Recent studies suggest that these genetic variations contribute to the break in humoral tolerance that allows for nucleic acid binding autoantibodies, and that the same polymorphisms also augment IFN-I production in the presence of these autoantibody immune complexes, forming a feed-forward loop. In this review, we will outline major features of the PRR/IRF systems and describe the role of the IRFs in human SLE pathogenesis. Copyright © 2015 Elsevier Inc. All rights reserved.

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