• Transl Res · Oct 2019

    Review

    CTC analysis: an update on technological progress.

    • Izhar S Batth, Abhisek Mitra, Sierra Rood, Scott Kopetz, David Menter, and Shulin Li.
    • Department of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    • Transl Res. 2019 Oct 1; 212: 14-25.

    AbstractThere is a growing need for a more accurate, real-time assessment of tumor status and the probability of metastasis, relapse, or response to treatment. Conventional means of assessment include imaging and tissue biopsies that can be highly invasive, may not provide complete information of the disease's heterogeneity, and not ideal for repeat analysis. Therefore, a less-invasive means of acquiring similar information at greater time points is necessary. Liquid biopsies are samples of a patients' peripheral blood and hold potential of addressing these criteria. Ongoing research has revealed that a tumor can release circulating cells, genetic materials (DNA or RNA), and exosomes into circulation. These potential biomarkers can be captured in a liquid biopsy and analyzed to determine disease status. To achieve these goals, numerous technologies have been developed. In this review, we discuss both prominent and newly developed technologies for circulating tumor cell capture and analysis and their clinical impact.Copyright © 2019 Elsevier Inc. All rights reserved.

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