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- Melissa L Jagrosse, David A Dean, Arshad Rahman, and Bradley L Nilsson.
- Department of Chemistry, University of Rochester, Rochester, New York.
- Transl Res. 2019 Dec 1; 214: 304930-49.
AbstractAcute respiratory distress syndrome (ARDS), replacing the clinical term acute lung injury, involves serious pathophysiological lung changes that arise from a variety of pulmonary and nonpulmonary injuries and currently has no pharmacological therapeutics. RNA interference (RNAi) has the potential to generate therapeutic effects that would increase patient survival rates from this condition. It is the purpose of this review to discuss potential targets in treating ARDS with RNAi strategies, as well as to outline the challenges of oligonucleotide delivery to the lung and tactics to circumvent these delivery barriers.Copyright © 2019 Elsevier Inc. All rights reserved.
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