• Transl Res · Jun 2020

    Review

    Topical application of bacteriophages for treatment of wound infections.

    • Rachel Yoon Kyung Chang, Sandra Morales, Yuko Okamoto, and Hak-Kim Chan.
    • Advanced Drug Delivery Group, The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, New South Wales, Australia.
    • Transl Res. 2020 Jun 1; 220: 153166153-166.

    AbstractWound infections associated with multidrug-resistant (MDR) bacteria are one of the important threats to public health. Bacteriophage (phage) therapy is a promising alternative or supplementary therapeutic approach to conventional antibiotics for combating MDR bacterial infections. In recent years, significant effort has been put into the development of phage formulations and delivery methods for topical applications, along with preclinical and clinical uses of phages for the treatment of acute and chronic wound infections. This paper reviews the application of phages for wound infections, with focus on the current status of phage formulations (including liquid, semi-solid and liposome-encapsulated formulations, phage-immobilized wound dressings), safety and efficacy assessment in clinical settings and major challenges to overcome.Copyright © 2020 Elsevier Inc. All rights reserved.

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