• Transl Res · Jun 2020

    Review

    Systems approaches for the clinical diagnosis of Clostridioides difficile infection.

    • Qinglong Wu and Tor C Savidge.
    • Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas.
    • Transl Res. 2020 Jun 1; 220: 57-67.

    AbstractClostridioides difficile infection (CDI) is an urgent threat to global public health. Patient susceptibility to C. difficile is highly dependent on host immune status and gut dysbiosis resulting in loss of protective microbiota consortia that prevent spore germination, pathogen colonization, and disease pathogenesis. Recent clinical studies highlight the problems of differentiating symptomatic CDI from asymptomatic C. difficile carriage in patients with diarrhea. In this review, we consider how integration of microbiome and host immune systems biology data may aid in the clinical diagnosis of CDI when validated against gold standard testing and combined with standard microbiology laboratory assays.Copyright © 2020 Elsevier Inc. All rights reserved.

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