• Sanish Sathyan and Joe Verghese.
• Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
• Transl Res. 2020 Jul 1; 221: 839683-96.

AbstractFrailty is a complex late life phenotype characterized by cumulative declines in multiple physiological systems that increases the risk for disability and mortality. The biological changes associated with aging are risk factors for frailty as well as for complex diseases; whereas longevity is assumed to be an outcome of protective biological mechanisms. Understanding the interplay between biological alterations associated with aging and protective mechanisms associated with longevity in the context of frailty may help guide development of interventions to increase healthspan and promote successful aging. The complexity of these phenotypes and relatively low heritability in studies are the main roadblocks in deciphering genetic mechanisms of these age associated conditions. We review genetic research related to frailty, and discuss the possible intertwined biology of frailty and longevity.Copyright © 2020 Elsevier Inc. All rights reserved.

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