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- Zhilin Chen and Boris Julg.
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
- Transl Res. 2020 Sep 1; 223: 61-75.
AbstractDespite the success of anti-retroviral therapy (ART) in transforming HIV into a manageable disease, it has become evident that long-term ART will not eliminate the HIV reservoir and cure the infection. Alternative strategies to eradicate HIV infection, or at least induce a state of viral control and drug-free remission are therefore needed. Therapeutic vaccination aims to induce or enhance immunity to alter the course of a disease. In this review we provide an overview of the current state of therapeutic HIV vaccine research and summarize the obstacles that the field faces while highlighting potential ways forward for a strategy to cure HIV infection.Copyright © 2020 Elsevier Inc. All rights reserved.
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