• Bangjian Zhang, Shaoqiong Sun, and Bo Sheng.
• Department of Anesthesiology.
• Medicine (Baltimore). 2020 May 1; 99 (19): e20147e20147.

BackgroundReduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compare the efficiency of multiple versus single doses of dexamethasone for early postoperative pain treatment after THA.MethodsThis study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion.ResultsThis clinical trial might provide some insights to estimate the safety of dexamethasone.Trial RegistrationThis study protocol was registered in Research Registry (researchregistry5460).

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