• Zhenni Mu, Jingyan Song, Yi Yu, and Zhengao Sun.
• Traditional Chinese Medicine Institute, Shandong University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 May 1; 99 (20): e20199.

IntroductionResistance ovary syndrome (ROS) is a disease characterized by hypergonadotropic amenorrhea but with normal ovarian reserve. Currently, its pathogenesis is still unclear and the treatment methods are complex. Nevertheless, there are evident negative effects of this disease on females' physical and mental health such as gonadal dysplasia, infertility, anxiety, and depression. This article reports a case of successful ovulation induction and pregnancy with letrozole combined with HMG. This can provide clinical treatment guidelines for the disease.Patient ConcernsThe patient underwent several hormone replacement cycles and ovulation induction cycles. But the dominant follicles were not extracted even after using large doses of gonadotropin.DiagnosisResistant ovary syndrome; Primary infertility INTERVENTIONS:: Larger doses of letrozole combined with HMG were injected to stimulate ovulation and sensitize the ovaries during menstruation. This helped to examine the peripheral effects of letrozole in relation to gonadotropin.OutcomesThe patient displayed a dominant follicular growth and notable ovulation which resulted in a full-term pregnancy and successful delivery.ConclusionsThe resistance ovary syndrome (ROS) can be treated and the findings from this case provides a possible treatment for ROS patients with infertility.

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