• Tie-Jun Li, Yu-Chen Sun, Qiu-Yan Ma, Yan Wu, Chao Yang, Nan Zhang, Yue Yang, and Ying-Xin Yang.
• Beijing Hospital of Traditional Chinese Medicine, Capital Medical University.
• Medicine (Baltimore). 2020 May 22; 99 (21): e20173.

IntroductionRetinal vein occlusion refers to diseases with decreased vision, dilated tortuous retinal veins visible on the fundus, and retinal hemorrhage, edema, and osmosis distributed along the vein. There is still no ideal intervention to treat central retinal vein occlusion. This study plan to observe the efficacy of Dan-Hong Hua-Yu oral solution in treating non-ischemic retinal vein occlusion, in order to provide new treatment ideas.Methods/DesignWe plan to use random number table method, 64 cases of non-ischemic central retinal vein occlusion that meet the inclusion criteria will be randomly divided into a treatment group and a control group. The intervention group will be treated with Dan-Hong Hua-Yu oral solution according to the syndrome differentiation of Traditional Chinese medicine and the patient's fundus condition. Each group will take 4 weeks as a course of treatment and three consecutive courses of treatment without any interval during the course of treatment. Changes of visual acuity, fundus performance, and total clinical symptoms of patients before and after treatment will be observed.DiscussionThis study will observe the efficacy of Dan-Hong Hua-Yu oral solution in the treatment of non-ischemic central retinal vein occlusion, with a view to providing new treatment ideas.Trial RegistrationClinicalTrials.gov, ChiCTR2000030625, Registered on March 08, 2020.

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