• Cleve Clin J Med · Dec 2019

    Review

    Beyond depression: Other uses for tricyclic antidepressants.

    • Joanne Schneider, Mary Patterson, and Xavier F Jimenez.
    • Center for Comprehensive Pain Recovery, Neurological Institute, Cleveland Clinic.
    • Cleve Clin J Med. 2019 Dec 1; 86 (12): 807-814.

    AbstractTricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.Copyright © 2019 Cleveland Clinic.

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