• J. Korean Med. Sci. · May 2020

    Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population.

    • Chang Kyun Choi, Sun Seog Kweon, Sang Hee Cho, Hye Yeon Kim, and Min Ho Shin.
    • Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
    • J. Korean Med. Sci. 2020 May 4; 35 (17): e148e148.

    AbstractThe association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 (ALDH2) polymorphism. Therefore, we investigated the relationship between the ALDH2 rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The ALDH2 rs671 genotype was classified as inactive ALDH2 (GG) or active ALDH2 (GA/AA). The risk of gastric cancer was higher in men with the inactive ALDH2 than in those with active ALDH2 (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09-1.39), whereas no significant association was found between ALDH2 genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99-1.02). In men, the association between ALDH2 genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive ALDH2 and high risk of gastric cancer.© 2020 The Korean Academy of Medical Sciences.

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