• Marina Rastović, Biljana Srdić-Galić, Barak Otto O 1Subotica General Hospital, Department of Internal Medicine, Division of Endocrinology, Subotica, Serbia; 2University of Novi Sad, Faculty of Medicine, Depar, Edita Stokić, and Snežana Polovina.
• 1Subotica General Hospital, Department of Internal Medicine, Division of Endocrinology, Subotica, Serbia; 2University of Novi Sad, Faculty of Medicine, Department of Anatomy, Novi Sad, Serbia; 3University of Novi Sad, Faculty of Medicine, Department of Physiology, Novi Sad, Serbia; 4University of Novi Sad, Faculty of Medicine, Institute of Internal Disease, Department of Endocrinology, Diabetes and Metabolic Disorders, Novi Sad, Serbia; 5Clinical Center of Serbia, Department of Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia; 6University of Novi Sad, Faculty of Pharmacy, Department of Internal Medicine, Novi Sad, Serbia.
• Acta Clin Croat. 2019 Sep 1; 58 (3): 430-438.

AbstractThe relationship between aging and changes in heart rate variability (HRV) could depend on the metabolic profile of obese people, i.e. metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). We aimed to determine the age at which obesity related autonomic dysfunction becomes significant and whether it decreases differently according to metabolic profile. We analyzed HRV in 99 adults using Wildman's criteria for metabolic profile and 5-minute HRV for autonomic nervous system. In MHO, high frequency (HF) decreased in the 4th decade of life. In MUO, standard deviation of R-R intervals (SDNN), root mean square of successive differences of all R-R intervals (RMSSD), number of adjacent intervals differing by more than 50 ms expressed as percentage of all intervals in the collecting period (pNN50), HF, low frequency (LF), LF/HF (LF divided by HF) and total power (TP) decreased in the 4th decade of life (partial shared variance 28%-36%). In conclusion, an age dependent decrease of HRV occurs in MUO between the third and fifth decade of life. In MHO, HF significantly decreases around the age of 40 years. Cardiometabolic profile influences metabolic aging, altering the autonomic nervous system.

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