European journal of nuclear medicine and molecular imaging
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Eur. J. Nucl. Med. Mol. Imaging · Sep 2004
Comparative Study Clinical Trial Controlled Clinical TrialPositron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate.
(11)C-metomidate (MTO), a marker of 11beta-hydroxylase, has been suggested as a novel positron emission tomography (PET) tracer for adrenocortical imaging. Up to now, experience with this very new tracer is limited. The aims of this study were (1) to evaluate this novel tracer, (2) to point out possible advantages in comparison with( 18)F-fluorodeoxyglucose (FDG) and (3) to investigate in vivo the expression of 11beta-hydroxylase in patients with primary aldosteronism. ⋯ MTO could not definitely distinguish between benign and malignant disease. FDG PET, however, identified clearly all three study patients with malignant adrenal lesions. We conclude: (1) MTO is an excellent imaging tool to distinguish adrenocortical and non-cortical lesions; (2) the in vivo expression of 11beta-hydroxylase is lower in Cushing's syndrome than in Conn's syndrome, and there is no suppression of the contralateral gland in primary aldosteronism; (3) for the purpose of discriminating between benign and malignant lesions, FDG is the tracer of choice.
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Eur. J. Nucl. Med. Mol. Imaging · Sep 2004
Clinical Trial Controlled Clinical TrialClinical utility of co-registered respiratory-gated( 99m)Tc-Technegas/MAA SPECT-CT images in the assessment of regional lung functional impairment in patients with lung cancer.
The aim of the study was to provide preliminary validation of the utility of co-registered respiratory-gated ventilation/perfusion single-photon emission computed tomography-computed tomography (SPECT-CT) images in the assessment of regional lung functional impairment in patients with lung cancer. ⋯ Detailed functional-morphological correlation on co-registered gated SPECT-CT images contributes to accurate assessment of regional functional impairment, and may be useful for surgical planning, prediction of postoperative function and assessment of external beam radiotherapy effects in patients with lung cancer.