African health sciences
-
African health sciences · Jun 2013
Case Reports Historical ArticleNodding syndrome: origins and natural history of a longstanding epileptic disorder in sub-Saharan Africa.
Repetitive involuntary head nodding was first reported in the 1960s in the Wapogoro tribe of Tanzania. ⋯ Historical accounts of head nodding (amesinzia kichwa, Swahili) among the Wapogoro tribe fit the August 2012 World Health Organization (WHO) case definition of probable Nodding Syndrome. Reported to have existed in this population for at least 80 years, Nodding Syndrome is a progressive seizure disorder that leads to generalized convulsions (kifafa), brain damage and death.
-
African health sciences · Jun 2013
The outcome of non-carbapenem-based empirical antibacterial therapy and VRE colonisation in patients with hematological malignancies.
Febrile neutropenia (FN) is generally a complication of cancer chemotherapy. ⋯ Our results suggest that initiating of non-carbapenem based therapy does not provide high response rates in the treatment of febrile neutropenia attacks. Furthermore, non-carbapenem-based empirical therapy provides benefit in regard to cost-effectiveness and antimicrobial stewardship when local antibiotic resistance patterns of gram-negative bacteria are considered. Patients who are colonized with VRE are more likely to develop bacteremia with VRE strains as a result of invasive procedures and severe damage of mucosal barriers observed in this group of patients.