African health sciences
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African health sciences · Dec 2017
Randomized Controlled TrialPlasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei.
Human African trypanosomiasis is one of the neglected and re-emerging infectious diseases in Africa with over 60 million people being at risk of contracting the disease. ⋯ T.b.brucei infection causes histological changes in both the paraventricular nucleus and pituitary gland in rats. These histological changes could account for the decrease in corticotropin releasing hormone (CRH) and ACTH production in the infected rats.