African health sciences
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African health sciences · Mar 2017
In vitro investigation of clofazimine analogues for antiplasmodial, cytotoxic and pro-oxidative activities.
Tetramethyl-piperidine-substituted, B4119 and B4158 have been shown to exhibit antiplasmodial activity. ⋯ Tetramethylpiperidyl-subsituted phenazines may potentially be useful antimalarial/antitumor agents with no pro-oxidative properties. In vivo studies on the agents relative to these properties are recommended.