African health sciences
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African health sciences · Dec 2018
GATA4 molecular screening and assessment of environmental risk factors in a Moroccan cohort with tetralogy of Fallot.
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD) with an incidence of 1/3600 live births. This disorder was associated with mutations in the transcription factors involved in cardiogenesis, like Nk2 homeobox5 (NKX2-5), GATA binding protein4 (GATA4) and T-BOX1 (TBX1). GATA4 contributes particularly to heart looping and differentiation of the second heart field. ⋯ The present study allowed, for the first time, the molecular and environmental characterisation of Moroccan TOF population. Our findings emphasise particularly the strong association of passive smoking with the emergence of tetralogy of Fallot.
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African health sciences · Dec 2018
Breast cancer resistance protein (BCRP) gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia.
Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is ambiguous. ⋯ The significance of BCRP gene expression and its function in AML is very complicated, therefore more standardized clinical studies are needed.
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African health sciences · Dec 2018
The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis.
Brucellosis is a zoonosis that affects several systems, especially with the osteoarticular involvement. ⋯ The NLR, MLR, ESR and CRP are useful parameters to estimate the clinical course of patients with brucellosis, and the NLR and MLR are alternative to inflammatory markers in the osteoarticular involvement.
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African health sciences · Dec 2018
Feeding difficulties in infants with unrepaired cleft lip and palate and HIV-exposure.
There is limited description of the feeding characteristics of infants with unrepaired cleft lip and palate, exposed to HIV, but not necessarily infected. ⋯ The research group presented with distinctive symptoms of oropharyngeal dysphagia. More studies using different measuring tools are required to strengthen the evidence.
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African health sciences · Dec 2018
CA 125 is a better marker to differentiate endometrial cancer and abnormal uterine bleeding.
Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB. ⋯ As individual tumor marker, serum CA 125 has the ability to detect endometrial cancer in patients with abnormal uterine bleeding.