African health sciences
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African health sciences · Jun 2022
Lack of FLT3-ITD in Tunisian childhood acute lymphoblastic leukemia.
The fms-like tyrosine kinase 3 (FLT3) gene belong to the class III receptor tyrosine kinases witch is predominantly expressed on hematopoietic progenitor cells, and plays an important role in haematopoiesis. Targeting the FMS-like tyrosine kinase receptor-3 (FLT3) in acute leukemia is mainly important. Therefore, activating mutations in FLT3, primarily the FLT3-internal tandem duplication (FLT3-ITD), was used as a prognostic marker especially in myeloid leukemia; however, in ALL, the prognostic relevance of FLT3 mutations is less clear. ⋯ Our findings suggest that FLT3 mutations are not common in Tunisian childhood ALL and thus do not affect clinical outcome.
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African health sciences · Jun 2022
Observational StudyPrevalence of venous thromboembolism risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu Nigeria.
Venous thromboembolism (VTE) is a common and lethal disease. Assessing the risk factors will help to modify exposures. ⋯ This study shows a high prevalence of VTE risk factors among hospitalized patients at the University of Nigeria Teaching Hospital.
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African health sciences · Jun 2022
Bibliometric analysis of the African Health Sciences' research indexed in Web of Science and Scopus.
The Journal of African Health Sciences (AHS) is an internationally refereed journal in the field of health sciences with vast research contributions in the world and Africa region. ⋯ This analysis has revealed the progress in the development and growth of scientific research from AHS. Moreover, top-cited documents-analysis has reflected its focus on health issues relevant to Africa. This analysis would help in evidence-based descriptions of AHS research output.
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African health sciences · Jun 2022
Perceived barriers and facilitators to antiretroviral therapy adherence among youth aged 15-24 years at a regional HIV clinic in SouthWestern Uganda: a qualitative study.
South-Western region has the second highest HIV prevalence in Uganda. Youth aged 15-24 have shown poor adherence to antiretroviral therapy compared to the older cohorts. Previous studies from other regions have shown various barriers and facilitators. Our study was designed to describe specific barriers and facilitators to treatment adherence among youths in a large regional HIV clinic in southwestern Uganda. ⋯ Youths aged 15-24 have challenges with ART associated treatment burden and fear to disclose their HIV status because of the resultant stigma from their communities. Many have however accepted the fact that HIV medications are lifesaving and are strongly motivated to adhere to their medications despite the circumstances.
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African health sciences · Jun 2022
Socio-economic status as predictors of malaria transmission in KwaZulu-Natal, South Africa. A retrospective study.
Understanding the socioeconomic status that influences malaria transmission in KwaZulu-Natal, South Africa is vital in creating policies and strategies to combat malaria transmission, improve socioeconomic conditions and strengthen the malaria elimination campaign. ⋯ Low socioeconomic status potentially sustains malaria transmission and burden. As an implication, poverty alleviation and malaria intervention resources should be incorporated side by side into the socioeconomic framework to attain zero malaria transmission.