African health sciences
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African health sciences · Sep 2022
Investigation of 13q14.3 deletion by cytogenetic analysis and FISH technique and miRNA-15a and miRNA-16-1 by real time PCR in chronic lymphocytic leukemia.
The most frequent cytogenetic aberration is 13q14.3 deletion in Chronic Lymphocytic Leukemia (CLL). HsamiR-15a/hsa-miR-16-1 are tumor suppressor miRNAs encoded from 13q14.3 region. ⋯ We suggest that cytogenetic and iFISH analyses are complementary and use of DSP30+IL-2 is effective .in CLL. Decreased expression of hsa-miR-16-1 is remarkable.
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African health sciences · Sep 2022
An examination of variables associated with breast cancer early detection behaviors of women.
Breast cancer is a worldwide common public health problem, and it is quite important to know the factors preventing the early detection behaviors to fight against it. ⋯ Early detection practices of women are not sufficient in our study. An increase in the knowledge level of women and consideration of the variables determined to be effective in early detection behaviors will allow increasing detection behavior.
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African health sciences · Sep 2022
Barriers and facilitators to adherence for antiretroviral therapy: the perspectives of patients from a wellness center in the Mpumalanga Province, South Africa.
Patients' non-adherence to antiretroviral treatment remains a public health concern in many developing countries, especially in South Africa. ⋯ Barriers and facilitators for adherence included several factors related to the health system, health care workers, and the patients. Achievement of optimal adherence to ART requires the commitment of both patients and providers.
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African health sciences · Sep 2022
Performance of the allometric power model in scaling from adult to paediatric antiretroviral dose in children at a Referral Hospital in Windhoek, Namibia.
World Health Organization (WHO) advocates use of weight bands in antiretroviral therapy (ART) guidelines. Allometric scaling could be a more reliable method because it uses a non-linear approach in relating dose to body weight. This study evaluates performance of the allometric ¾ power model in comparison to WHO weight band method in children receiving ART. ⋯ WHO weight bands may result in the 25 kg weight category receiving a much higher dose leading to ADRs. Using allometric scaling, we recommend a weight band strategy that could improve paediatric ABC/3TC dosing.